Effects of Sulforaphane on Health

There have been more than 1300 published studies made on the effects of sulforaphane / isothiocyanates found in broccoli sprout juice. We list a few below with research topics including:

Cancer & Carcinogens – Intestinal Health – Autism – Alzheimer’s Disease – Parkinson’s Disease – Skin Disorders – Aging – Eyes – Air Pollution – Diseases caused by Protein Misfolding

Cancer & Carcinogens

Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.

Fahey JW, Zhang Y, Talalay P.

Brassica Chemoprotection Laboratory and Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, USA

Proc. Natl. Acad. Sci. USA, Vol. 94, pp. 10367-10372, September 16, 1997.

Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells.

Singh SV, Warin R, Xiao D, Powolny AA, Stan SD, Arlotti JA, Zeng Y, Hahm ER, Marynowski SW, Bommareddy A, Desai D, Amin S, Parise RA, Beumer JH, Chambers WH. 

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, USA

Cancer Res. 2009 Mar 1;69(5):2117-25. Epub 2009 Feb 17.

Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo.

V. Singh, D. Xiao, K. L. Lew, R. Dhir, S. V. Singh

Carcinogenesis, January 1, 2004; 25(1): 83 – 90.

Antimetastatic activity of Sulforaphane

Thejass and Girija Kuttan

Department of Immunology, Amala Cancer Research Centre, Amala Nagar,  India.

Life Sciences Volume 78, Issue 26, 22 May 2006, Pages 3043-3050

Intestinal Health

Oral broccoli sprouts for the treatment of Helicobacter pylori infection: a preliminary report.

[H.pylori infection is associated with stomach ulcers and stomach cancers]

Mark V. Galan, M.D., Arfana A. Kishan, M.D., Ann L. Silverman, M.D.*. 

William Beaumont Hospital, Royal Oak, MI.

The American Journal of Gastroenterology: Volume 98, Issue 9, Supplement 1 , September 2003, Page S57

Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans.

Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, Tauchi M, Suzuki H, Hyodo I, Yamamoto M. 

Division of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan.

Cancer Prev Res (Phila Pa). 2009 Apr;2(4):353-60

Broccoli ( Brassica oleracea var. italica) sprouts and extracts rich in glucosinolates and isothiocyanates affect cholesterol metabolism and genes involved in lipid homeostasis in hamsters.

Rodríguez-Cantú LN, Gutiérrez-Uribe JA, Arriola-Vucovich J, Díaz-De La Garza RI, Fahey JW, Serna-Saldivar SO. 

Departamento de Biotecnología e Ingeniería de Alimentos, Tecnológico de Monterrey, Mexico.

J Agric Food Chem. 2011 Feb 23;59(4):1095-103. Epub 2011 Jan 21.

Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway

Riedl MA, Saxon A, Diaz-Sanchez D. 

The Hart and Louis Laboratory, Clinical Immunology and Allergy, Department of Medicine, UCLA David Geffen School of Medicine.

[Ashma] Clin Immunol. 2008 Nov 21.

Sulforaphane Protects Small Intestinal Mucosa From Aspirin/NSAID-Induced Injury by Enhancing Host Defense Systems Against Oxidative Stress and by Inhibiting Mucosal Invasion of Anaerobic Enterobacteria

Yanaka A, Sato J, Ohmori S. 

Hitachi Medical Education and Research Center, Faculty of Medicine, University of Tsukuba Hospital 2-1-1, Jonan-cho, Hitachi-shi, Ibaraki-ken, 317-0077, Japan.

Curr Pharm Des. 2012 Aug 23.

Autism

Sulforaphane treatment of autism spectrum disorder (ASD)

Singh K1234, Susan L. Connors123, Eric A. Macklin35Kirby D. Smith6, Jed W Fahey78, Paul Talalay78, Andrew W. Zimmerman134

1Lurie Center for Autism

2Department of Pediatrics, Massachusetts General Hospital for Children,

3Harvard Medical School

4Department of Pediatrics (Neurology), University of Massachusetts Medical School

5Department of Medicine, Massachusetts General Hospital Biostatistics Enter

6McKusick-Nathans Institute for Genetic Medicine and.

7Department of Pharmacology and Molecular Sciences, Lewis B. and Dorothy Cullman Chemoprotection Center

8The Johns Hopkins University School of Medicine, Baltimore.

PNAS October 28, 2014 vol. 111no. 43 15550-15555

Autism Trial Support Group on Facebook.
In 2015, a test was conducted with 40 children with autism who showed the fever response. Some children took part in the test even if it was not known if they showed the fever response, since not all of them had had a fever. Children were asked to drink a tube of broccoli sprout juice a day for 4 weeks. Not all of them managed to drink the juices (mainly due to taste), but despite this, 50% of those participating showed an improvement. Click to read parents’ comments.

Alzheimer’s Disease

Amelioration of Alzheimer’s disease by neuroprotective effect of sulforaphane in animal model.

Kim HV1, Kim HY, Ehrlich HY, Choi SY, Kim DJ, Kim Y. Amyloid

1Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea

2013 Mar;20(1):7-12. doi: 10.3109/13506129.2012.751367. Epub 2012 Dec 19.

Parkinson’s Disease

Sulforaphane Protects Cortical Neurons against Endogenous Neurotoxins in a Model of Parkinson’s Disease

Vauzour14, M. Buonfiglio2, G. Corona1, J. Chirafisi1, K. Vafeiadou1, C., Angeloni2, Hrelia2, P. Hrelia3 and J.P.E. Spencer1

1Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, The University of Reading, UK.

2Department of Biochemistry “G. Moruzzi”, University of Bologna, Italy.

3Department of Pharmacology, University of Bologna, Italy.

4Present address: Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, UK.

Skin Disorders

Isothiocyanates inhibit psoriasis-related proinflammatory factors in human skin.

Yehuda H1, Soroka Y, Zlotkin-Frušić M, Gilhar A, Milner Y, Tamir S.

1Laboratory of Human Health and Nutrition Sciences, MIGAL-Galilee Technology Center, Israel.

Inflamm Res. 2012 Jul;61(7):735-42. doi: 10.1007/s00011-012-0465-3. Epub 2012 Mar 28.

Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex.

L. Kerns1, D. DePianto, A. T. Dinkova-Kostova, P. Talalay, P. A. Coulombe

1Department of Biological Chemistry, John Hopkins University School of Medicine, Baltimore.

PNAS, September 4, 2007; 104(36): 14460 – 14465.

Aging

Nrf2 activation by sulforaphane restores the age-related decrease of TH1 immunity: Role of dendritic cells: Reverses aging mechanisms in immune system

H.-J. Kim1, B. Barajas, M. Wang, A.E. Nel

1Division of NanoMedicine, Department of Medicine, University of California.

Journal of Allergy and Clinical Immunology (Elsevier) – Published online ahead of print 5 March 2008, doi:10.1016/j.jaci.2008.01.016

Sulforaphane Represses Matrix-Degrading Proteases and Protects Cartilage From Destruction In Vitro and In Vivo 

Rose K. Davidson1, Orla Jupp, Rachel de Ferrars, Colin D. Kay, Kirsty L. Culley, Rosemary Norton, Clare Driscoll, Tonia L. Vincent, Simon T. Donell, Yongping Bao, Ian M. Clark

1University of East Anglia, Norwich, UK.

ARTHRITIS & RHEUMATISM Vol. 65, No. 12, December 2013, pp 3130–3140 DOI 10.1002/art.38133

Eyes

Molecular mechanisms underlying cochlear [and macular] degeneration in the tubby mouse and the therapeutic effect of sulforaphane.

Kong L, Chen GD, Zhou X, McGinnis JF, Li F, Cao W.

Department of Ophthalmology and Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, USA.

Neurochem Int. 2009 Mar-Apr;54(3-4):172-9. Epub 2008 Dec 9.

Sulforaphane Induces Thioredoxin through the Antioxidant-Responsive Element and Attenuates Retinal Light Damage in Mice

Tanito M1, H. Masutani, Y.-C. Kim, M. Nishikawa, A. Ohira, and J. Yodoi

1Department of Biological Responses, Institute for Virus Research, Kyoto University, Japan.

Invest. Ophthalmol. Vis. Sci., March 1, 2005; 46(3): 979 – 987.

Air Pollution

Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China.

Egner PA1, Chen JG2, Zarth AT3, Ng DK4, Wang JB2, Kensler KH1, Jacobson LP4, Muñoz A4, Johnson JL1, Groopman JD1, Fahey JW5Talalay P5Zhu J2, Chen TY2, Qian GS2, Carmella SG3, Hecht SS3, Kensler TW6

1Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 USA.

2Qidong Liver Cancer Institute, Qidong, Jiangsu, 226200 China.

3Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455 USA.

4Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 USA.

5Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205 USA.

6Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261 USA.

Cancer Prev Res (Phila). 2014 Aug;7(8):813-23. doi: 10.1158/1940-6207.CAPR-14-0103. Epub 2014 Jun 9.

Please see the Dangers of Exercise

***Diseases caused by Protein Misfolding***

This is one of THE most important studies ever carried out on sulforaphane because it shows how sulforaphane helps stop a crucial mechanism called protein misfolding that causes many diseases including Type 2 Diabetes, Dementia, Huntingdon’s Disease, Cystic Fibrosis, Sickle Cell Disease and Cataracts.

The amyloid state and its association with protein misfolding diseases.

Knowles TP, Vendruscolo M, Dobson CM

Department of Chemistry, University of Cambridge, UK

Nat Rev Mol Cell Biol. 2014 Jul;15(7):496.

Abstract: The phenomenon of protein aggregation and amyloid formation has become the subject of rapidly increasing research activities across a wide range of scientific disciplines. Such activities have been stimulated by the association of amyloid deposition with a range of debilitating medical disorders, from Alzheimer’s disease to type II diabetes, many of which are major threats to human health and welfare in the modern world. It has become clear, however, that the ability to form the amyloid state is more general than previously imagined, and that its study can provide unique insights into the nature of the functional forms of peptides and proteins, as well as understanding the means by which protein homeostasis can be maintained and protein metastasis avoided.

[Effectively, this study suggests that this mis-folding of proteins is the genesis of many conditions associated with neurological development or neurological decay. Other studies indicate that sulforaphanes can stop or reverse this mis-folding.]

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