What is Sulforaphane?
Let’s understand more about the tiny molecule that has provoked so much interest.
Effects of Sulforaphane on Health
Cancer & Carcinogens – Intestinal Health – Autism – Alzheimer’s Disease – Parkinson’s Disease – Skin Disorders – Aging – Eyes – Air Pollution – Diseases caused by Protein Misfolding
The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.
N.-A. Pham, J. W. Jacobberger, A. D. Schimmer, P. Cao, M. Gronda, D. W. Hedley
Mol. Cancer Ther., October 1, 2004; 3(10): 1239 – 1248.
Fahey JW, Zhang Y, Talalay P.
Brassica Chemoprotection Laboratory and Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, USA
Proc. Natl. Acad. Sci. USA, Vol. 94, pp. 10367-10372, September 16, 1997.
Singh SV, Warin R, Xiao D, Powolny AA, Stan SD, Arlotti JA, Zeng Y, Hahm ER, Marynowski SW, Bommareddy A, Desai D, Amin S, Parise RA, Beumer JH, Chambers WH.
Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, USA
Cancer Res. 2009 Mar 1;69(5):2117-25. Epub 2009 Feb 17.
V. Singh, D. Xiao, K. L. Lew, R. Dhir, S. V. Singh
Carcinogenesis, January 1, 2004; 25(1): 83 – 90.
Thejass and Girija Kuttan
Department of Immunology, Amala Cancer Research Centre, Amala Nagar, India.
Life Sciences Volume 78, Issue 26, 22 May 2006, Pages 3043-3050
[H.pylori infection is associated with stomach ulcers and stomach cancers]
Mark V. Galan, M.D., Arfana A. Kishan, M.D., Ann L. Silverman, M.D.*.
William Beaumont Hospital, Royal Oak, MI.
The American Journal of Gastroenterology: Volume 98, Issue 9, Supplement 1 , September 2003, Page S57
Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, Tauchi M, Suzuki H, Hyodo I, Yamamoto M.
Division of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan.
Cancer Prev Res (Phila Pa). 2009 Apr;2(4):353-60
Rodríguez-Cantú LN, Gutiérrez-Uribe JA, Arriola-Vucovich J, Díaz-De La Garza RI, Fahey JW, Serna-Saldivar SO.
Departamento de Biotecnología e Ingeniería de Alimentos, Tecnológico de Monterrey, Mexico.
J Agric Food Chem. 2011 Feb 23;59(4):1095-103. Epub 2011 Jan 21.
Riedl MA, Saxon A, Diaz-Sanchez D.
The Hart and Louis Laboratory, Clinical Immunology and Allergy, Department of Medicine, UCLA David Geffen School of Medicine.
[Ashma] Clin Immunol. 2008 Nov 21.
Sulforaphane Protects Small Intestinal Mucosa From Aspirin/NSAID-Induced Injury by Enhancing Host Defense Systems Against Oxidative Stress and by Inhibiting Mucosal Invasion of Anaerobic Enterobacteria
Yanaka A, Sato J, Ohmori S.
Hitachi Medical Education and Research Center, Faculty of Medicine, University of Tsukuba Hospital 2-1-1, Jonan-cho, Hitachi-shi, Ibaraki-ken, 317-0077, Japan.
Curr Pharm Des. 2012 Aug 23.
Singh K1234, Susan L. Connors123, Eric A. Macklin35, Kirby D. Smith6, Jed W Fahey78, Paul Talalay78, Andrew W. Zimmerman134
1Lurie Center for Autism
2Department of Pediatrics, Massachusetts General Hospital for Children,
3Harvard Medical School
4Department of Pediatrics (Neurology), University of Massachusetts Medical School
5Department of Medicine, Massachusetts General Hospital Biostatistics Enter
6McKusick-Nathans Institute for Genetic Medicine and.
7Department of Pharmacology and Molecular Sciences, Lewis B. and Dorothy Cullman Chemoprotection Center
8The Johns Hopkins University School of Medicine, Baltimore.
PNAS October 28, 2014 vol. 111no. 43 15550-15555
Autism Trial Support Group on Facebook.
In 2015, a test was conducted with 40 children with autism who showed the fever response. Some children took part in the test even if it was not known if they showed the fever response, since not all of them had had a fever. Children were asked to drink a tube of broccoli sprout juice a day for 4 weeks. Not all of them managed to drink the juices (mainly due to taste), but despite this, 50% of those participating showed an improvement. Click to read parents’ comments.
Kim HV1, Kim HY, Ehrlich HY, Choi SY, Kim DJ, Kim Y. Amyloid
1Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea
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Vauzour14, M. Buonfiglio2, G. Corona1, J. Chirafisi1, K. Vafeiadou1, C., Angeloni2, Hrelia2, P. Hrelia3 and J.P.E. Spencer1
1Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, The University of Reading, UK.
2Department of Biochemistry “G. Moruzzi”, University of Bologna, Italy.
3Department of Pharmacology, University of Bologna, Italy.
4Present address: Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, UK.
Yehuda H1, Soroka Y, Zlotkin-Frušić M, Gilhar A, Milner Y, Tamir S.
1Laboratory of Human Health and Nutrition Sciences, MIGAL-Galilee Technology Center, Israel.
Inflamm Res. 2012 Jul;61(7):735-42. doi: 10.1007/s00011-012-0465-3. Epub 2012 Mar 28.
L. Kerns1, D. DePianto, A. T. Dinkova-Kostova, P. Talalay, P. A. Coulombe
1Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore.
PNAS, September 4, 2007; 104(36): 14460 – 14465.
H.-J. Kim1, B. Barajas, M. Wang, A.E. Nel
1Division of NanoMedicine, Department of Medicine, University of California.
Journal of Allergy and Clinical Immunology (Elsevier) – Published online ahead of print 5 March 2008, doi:10.1016/j.jaci.2008.01.016
Rose K. Davidson1, Orla Jupp, Rachel de Ferrars, Colin D. Kay, Kirsty L. Culley, Rosemary Norton, Clare Driscoll, Tonia L. Vincent, Simon T. Donell, Yongping Bao, Ian M. Clark
1University of East Anglia, Norwich, UK.
Arthritis & Rheumatism Vol. 65, No. 12, December 2013, pp 3130–3140 DOI 10.1002/art.38133
Kong L, Chen GD, Zhou X, McGinnis JF, Li F, Cao W.
Department of Ophthalmology and Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Neurochem Int. 2009 Mar-Apr;54(3-4):172-9. Epub 2008 Dec 9.
Tanito M1, H. Masutani, Y.-C. Kim, M. Nishikawa, A. Ohira, and J. Yodoi
1Department of Biological Responses, Institute for Virus Research, Kyoto University, Japan.
Invest. Ophthalmol. Vis. Sci., March 1, 2005; 46(3): 979 – 987.
Egner PA1, Chen JG2, Zarth AT3, Ng DK4, Wang JB2, Kensler KH1, Jacobson LP4, Muñoz A4, Johnson JL1, Groopman JD1, Fahey JW5, Talalay P5, Zhu J2, Chen TY2, Qian GS2, Carmella SG3, Hecht SS3, Kensler TW6
1Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 USA.
2Qidong Liver Cancer Institute, Qidong, Jiangsu, 226200 China.
3Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455 USA.
4Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 USA.
5Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205 USA.
6Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261 USA.
Cancer Prev Res (Phila). 2014 Aug;7(8):813-23. doi: 10.1158/1940-6207.CAPR-14-0103. Epub 2014 Jun 9.
Read more about air pollution control in Dangers of Exercise
This is one of THE most important studies ever carried out on sulforaphane because it shows how sulforaphane helps stop a crucial mechanism called protein misfolding that causes many diseases including Type 2 Diabetes, Dementia, Huntingdon’s Disease, Cystic Fibrosis, Sickle Cell Disease and Cataracts.
Knowles TP, Vendruscolo M, Dobson CM
Department of Chemistry, University of Cambridge, UK
Nat Rev Mol Cell Biol. 2014 Jul;15(7):496.
Abstract: The phenomenon of protein aggregation and amyloid formation has become the subject of rapidly increasing research activities across a wide range of scientific disciplines. Such activities have been stimulated by the association of amyloid deposition with a range of debilitating medical disorders, from Alzheimer’s disease to type II diabetes, many of which are major threats to human health and welfare in the modern world. It has become clear, however, that the ability to form the amyloid state is more general than previously imagined, and that its study can provide unique insights into the nature of the functional forms of peptides and proteins, as well as understanding the means by which protein homeostasis can be maintained and protein metastasis avoided.
[This study suggests that this mis-folding of proteins is the genesis of many conditions associated with neurological development or neurological decay. Other studies indicate that sulforaphane can stop or reverse this mis-folding.]